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Supercomplexes' Role in Cellular Energy Production and Disease Questioned

Supercomplexes Picture: Nils-Göran Larsson's lab

A recent study led by Professor Nils-Göran Larsson at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, challenges the notion that respiratory chain supercomplexes play a significant role in cellular energy production and disease. These supercomplexes are formed by protein complexes in mitochondria and have been proposed to have implications for various physiological processes and diseases, such as diabetes, metabolic disorders, heart failure, and cancer. However, the study's findings, based on a powerful mouse model, suggest that supercomplex formation is not essential for normal cellular energy homeostasis. The results question the potential of manipulating supercomplex formation as a treatment strategy for certain diseases and call for further exploration of alternate ways to regulate energy production.