New discoveries about where atherosclerotic plaques rupture can lead to preventive treatments

Researchers at Lund University have made progress in understanding the location and mechanisms of plaque rupture, a common cause of myocardial infarction and stroke. By studying atherosclerotic plaques in the carotid arteries of 188 individuals, the team identified that plaques often rupture at the beginning, closest to the heart. This detailed mapping of plaque rupture provides valuable insights into the process and may aid in preventing complications. The researchers also discovered a strong association between the enzyme MMP-9 and the area where plaques rupture. High levels of MMP-9 may indicate an increased risk of future cardiovascular disease. The researchers hope to use MMP-9 as a marker to predict the risk of heart attack or stroke and are exploring potential treatments to reduce plaque rupture risk. Their findings could help initiate preventive measures or timely treatment to address dangerous plaques before complications occur.