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A step towards solving the riddle of tumor cell invasion

Fluorescent protein stains of tumor growing in the liver. Photo: Marco Gerling, Carina Strell

Researchers from Karolinska Institutet and physicians at Karolinska Hospital have conducted a study that uncovers the role of connective tissue capsules around liver metastases from colorectal cancer. Contrary to previous assumptions, the presence of a capsule is associated with improved patient survival and represents a healing response by the liver, rather than a phenomenon caused by the tumor itself. The study utilized clinical samples and mouse models to trace the origins of the capsule, revealing its connection to liver fibrosis and a reparative process. Collaborative efforts between researchers and clinicians played a crucial role in gaining valuable insights into cancer cell invasion into healthy tissue.